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Young DA; Davila R & Scher H.
Schizophrenia Research, 10:117-124, 1993
RELEVANCE FOR EARLY INTERVENTION
This study reports on data that implicates frontal lobe
dysfunction in the etiology of poor insight in patients with chronic schizophrenia.
Previous authors had hypothesized that frontal lobe pathology may account for the severe
forms of unawareness frequently seen in certain psychotic disorders (see recommended
review article: Amador et al., 1991). Young and his colleagues tested this hypothesis
using neuropsychological tests and the Scale to assess Unawareness of Mental Disorder. The
results indicated that poor performance on tests of frontal function predicted poor
insight independent of other cognitive functions tested including IQ. These results lend
important support to the idea that poor insight into illness and resulting treatment
refusal stem from a mental defect rather than informed choice.
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