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Takai A; Uematsu M; Ueki H, Sone K and Kaiya Hisanobu.
European Journal of Psychiatry, 6:159-170, 1992.
RELEVANCE FOR EARLY INTERVENTION
Lack of insight into having an illness, defined by a single
item on the Present State Examination, was correlated with structural brain abnormalities.
Specifically, patients with poor insight into having an illness had increased ventricular
brain rations. Ventricular enlargement of the third ventricle was most strongly correlated
with poor insight. Meanwhile, IQ was not found to be significantly associated with insight
suggesting that the brain dysfunction underlying this deficit in self awareness may be
relatively specific rather than a consequence of a general decline in cognitive function.
This study is the first to show an association between structural brain abnormalities and
lower levels of insight in patients with chronic schizophrenia. It adds to the growing
body of literature that suggests that poor insight in this disorder is a consequence of a
mental defect.
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