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Briefing Paper
April 2007
Anosognosia as a cause of violent behavior in individuals with severe psychiatric disorders
SUMMARY: Anosognosia, unawareness of illness, is the most important reason individuals with severe psychiatric disorders do not take medication for their illness. Multiple studies have demonstrated that the presence of anosognosia increases the incidence of violent behavior, both because it is associated with medication nonadherence and because it appears to directly increase violent behavior.
Anosognosia is a major contributor to aggressive and violent behavior among individuals with severe psychiatric disorders. Because anosognosia is the major cause of medication nonadherence, the association can be assessed either by studying violent behavior and nonadherence or by studying violent behavior and measures of insight.
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1. Violent behavior and nonadherence
Many studies have been published linking aggressive and violent behavior to medication nonadherence. Following are three examples.
Bartels SJ, Drake RE, Wallach MA, et al. Characteristic hostility in schizophrenic patients. Schizophrenia Bulletin 17:163–171, 1991.
Ascher-Svanum H, Faries DE, Zhu B, et al. Medication adherence and long-term functional outcomes in the treatment of schizophrenia in usual care. Journal of Clinical Psychiatry 67:453–460, 2006
Elbogen EB, Van Dorn RA, Swanson JW, et al. Treatment engagement and violence risk in mental disorders. British Journal of Psychiatry 189:354–360, 2006.
2. Violent behavior and poor insight
Swartz MS, Swanson JW, Hiday VA, et al. Violence and severe mental illness: the effects of substance abuse and nonadherence to medication. American Journal of Psychiatry 155:226–231, 1998.
Arango C, Calcedo Barba A, González-Salvador T, et al. Violence in inpatients with schizophrenia: a prospective study. Schizophrenia Bulletin 25:493–503, 1999.
Strand S, Belfrage H, Fransson G, et al. Clinical and risk management factors in risk prediction of mentally disordered offenders—more important than historical data? Legal and Criminological Psychology 4:67–76, 1999.
Woods P, Reed V, Collins M. The relationship between risk and insight in a high-security forensic setting. Journal of Psychiatric and Mental Health Nursing 10:510–517, 2003.
Buckley PF, Hrouda DR, Friedman L, et al. Insight and its relationship to violent behavior in patients with schizophrenia. American Journal of Psychiatry 161:1712–1714, 2004.
Grevatt M, Thomas-Peter B, Hughes G. Violence, mental disorder and risk assessment: can structured clinical assessments predict the short-term risk of inpatient violence? Journal of Forensic Psychiatry and Psychology 15:278–292, 2004.
Foley SR, Kelly BD, Clarke M, et al. Incidence and clinical correlates of aggression and violence at presentation in patients with first episode psychosis. Schizophrenia Research 72:161–168, 2005.
Alia-Klein N, O’Rourke TM, Goldstein RZ et al. Insight into illness and adherence to psychotropic medications are separately associated with violence severity in a forensic sample. Aggressive Behavior 33:86–96, 2007.
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